Mike's cross-platform FreeEMS tuning application, written in C++ using QT. With Mike's natural coding talent and Fred's intimate requirement knowledge it went from concept to full tuning capability in just 8 weeks!
I get that message when it's trying to access the wrong COM port. If you go to Edit -> Settings you can change the port. It should probably be named something like "COM1" or "COM3".
If you need to figure out which port you're trying to use you could right click on My Computer, and then click on Properties. Then find a button called Device Manager I think which might be under a hardware tab, and find the COM ports. Then you could try every port installed port in emstudio or if the port is unpluggable just look to see which one disappears when you unplug it.
It could be probably be some other things also, but I don't know what they would be.